The Spurs will be looking to avenge their opening match on August 6 after Southampton won 3-2 with two goals in three minutes in the exact match last February.
Spurs’ poor form before securing Champions League football triggered a three-match losing streak in four league games, a win perhaps a surprise for Manchester City.
While Ralph Hassenhatl’s side may have to face a tough test, the next match will be an even tougher challenge as Thomas Tuchel’s visit to Chelsea for Tottenham’s first season of the season for the London derby.
Premier League champions City will visit on 10 September, but all eyes will be on 1 October when the Spurs visit Arsenal for the first time in a campaign between rivals in north London.
Conte’s side had to face a challenging final in April when they hosted Manchester United ahead of a away match against Liverpool, while Tottenham will end their top-flight season at Leeds United.
Tottenham 2022-23 Premier League full matches:
| Date | Opponents (at home or away) |
| 06/08/2022 | Southampton (HK) |
| 13/08/2022 | Chelsea (A) |
| 20/08/2022 | Tottenham (H) |
| 27/08/2022 | Nottingham Forest (A) |
| 30/08/2022 | West Ham (A) |
| 03/09/2022 | Fulham (H) |
| 10/09/2022 | Manchester City (A) |
| 17/09/2022 | Leicester City (HK) |
| 01/10/2022 | Arsenal (A) |
| 08/10/2022 | Brighton and Hove Albion (A) |
| 15/10/2022 | Everton (H) |
| 19/10/2022 | Manchester United (A) |
| 22/10/2022 | Newcastle United (HK) |
| 29/10/2022 | Bournemouth (A) |
| 05/11/2022 | Liverpool (HK) |
| 12/11/2022 | Leeds United (HK) |
| 26/12/2022 | Brentford (A) |
| 31/12/2022 | Aston Villa (H) |
| 02/01/2023 | Crystal Palace (A) |
| 14/01/2023 | Arsenal (H) |
| 21/01/2023 | Fulham (A) |
| 04/02/2023 | Manchester City (HK) |
| 11/02/2023 | Leicester City (A) |
| 18/02/2023 | West Ham (H) |
| 25/02/2023 | Chelsea (H) |
| 04/03/2023 | Wolf (A) |
| 11/03/2023 | Nottingham Forest (H) |
| 18/03/2023 | Southampton (A) |
| 01/04/2023 | Everton (A) |
| 08/04/2023 | Brighton and Hove Albion (HK) |
| 15/04/2023 | Bournemouth (HK) |
| 22/04/2023 | Newcastle United (A) |
| 25/04/2023 | Manchester United (HK) |
| 29/04/2023 | Liverpool (A) |
| 06/05/2023 | Crystal Palace (H) |
| 13/05/2023 | Aston Villa (A) |
| 20/05/2023 | Brentford (H) |
| 28/05/2023 | Leeds United (A) |