Cody Gakpo and Noah Lang’s first-half goals gave the hosts a two-goal lead, but a goal from Brennan Johnson and a stopped bell spot-kick held Wales to a draw.
However, Oranje Amulet Depe later won the championship to start a wild celebration in the home rankings.
The third win in four games at the end of a long season continued the strong Nations League campaign for the Netherlands, who remain at the top of the group while Wales are down and unbeaten.